Mechanistic Modeling of Tumor Repopulation during Radiation Treatments
نویسندگان
چکیده
منابع مشابه
Optimization of Radiation Therapy Fractionation Schedules in the Presence of Tumor Repopulation
W analyze the effect of tumor repopulation on optimal dose delivery in radiation therapy. We are primarily motivated by accelerated tumor repopulation toward the end of radiation treatment, which is believed to play a role in treatment failure for some tumor sites. A dynamic programming framework is developed to determine an optimal fractionation scheme based on a model of cell kill from radiat...
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The variety of treatment options for cancer patients has increased significantly in recent years. Not only do we combine radiation with surgery and chemotherapy, new therapeutic approaches such as immunotherapy and targeted therapies are starting to play a bigger role. Physics has made significant contributions to radiation therapy treatment planning and delivery. In particular, treatment plan ...
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The rate of repopulation of surviving cells increases during fractionated radiotherapy and limits the ability to control tumors. Repopulation is likely to be more important during the longer intervals between courses of chemotherapy and is a potential cause of clinical resistance to chemotherapy. To evaluate the rate of repopulation of surviving cells in MXT and EMT-6 mouse breast tumors betwee...
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ژورنال
عنوان ژورنال: Journal of Chemical Engineering & Process Technology
سال: 2015
ISSN: 2157-7048
DOI: 10.4172/2157-7048.1000226